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GLUCOZAMINĂ . CONDROITINĂ

GLUCOZAMINĂ . CONDROITINĂ

Prezentare scurtă

Un mare studiu al National Institutes of Health (NIH), numit Glucosamine / Condroitin Arthritis Intervention Trial (GAIT), a comparat clorhidratul de glucozamină, condroitina, ambele suplimente împreună, celecoxib (un medicament eliberat pe bază de rețetă utilizat pentru tratarea durerii osteoartritei) si un placebo (un substanță inactivă) la pacienții cu osteoartrita genunchiului.

 

Cei care au primit medicamentul eliberat pe bază de rețetă au avut o mai bună ameliorare a durerii pe termen scurt (la 6 luni) decât cei care au primit un placebo.

 

În general, cei care au primit suplimente nu au avut o îmbunătățire semnificativă a durerii sau funcției genunchiului, deși anchetatorii au observat dovezi de îmbunătățire la un subgrup mic de pacienți cu durere moderată până la severă care au luat împreună glucozamină și condroitină.

INTERACȚIUNI

🦴💊 Administrarea sulfatului de glucozamină și a acetaminofenului (paracetamol) ar putea reduce eficacitatea atât a suplimentului, cât și a medicamentului.

 

🦴💊  Administrarea de glucozamină în monoterapie sau în combinație cu suplimentul de condroitină poate crește efectele warfarinei, iar acest lucru poate crește riscul de sângerare.

 

🦴💊  Un studiu efectuat la șobolani a arătat că utilizarea pe termen lung a unor doze moderat mari de glucozamină ar putea afecta rinichii.

 

🦴💊 Studiile sugerează că sulfatul de glucozamină poate crește rezistența la insulină. Din acest motiv, pacienții diabetici trebuie să utilizeze sulfat de glucozamină cu precauție și numai cu acordul medicului.

bibliografie

  1. Glucosamine and chondroitin for osteoarthritis pain. Arthritis Foundation. https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/glucosamine-chondroitin-osteoarthritis-pain. Accessed Oct. 24, 2020.
  2. N-acetyl glucosamine (NAG). Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
  3. Osteoarthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/osteoarthritis. Accessed Oct. 24, 2020.
  4. Glucosamine sulfate. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
  5. Pizzorono JE, et al., eds. Glucosamine. In: Textbook of Natural Medicine. 5th ed. Elsevier, 2021. https://www.clinicalkey.com. Accessed Oct. 24, 2020.
  6. Vasiliadis HS, et al. Glucosamine and chondroitin for the treatment of osteoarthritis. World Journal of Orthopedics. 2017; doi:10.5312/wjo.v8.i1.1.
  7. Glucosamine hydrochloride. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
  8. Rubin BR, et al. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis. Journal of the American Osteopathic Association. 2001; https://jaoa.org/article.aspx?articleid=2092565. Accessed Oct. 28, 2020.
  9. Ali AA, Lewis SM, Badgley HL, et al. Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: implications for human efficacy and toxicity. Archives of Biochemistry and Biophysics. 2011;510(1):11–18.
  10. Cahlin BJ, Dahlström L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2011;112(6):760–766.
  11. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. 2006;354(8):795–808.
  12. Dostrovsky NR, Towheed TE, Hudson RW, et al. The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis and Cartilage. 2011;19(4):375–380.
  13. Gabay C, Medinger-Sadowski C, Gascon D, et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis & Rheumatism. 2011;63(11):3383–3391.
  14. Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis & Rheumatism. 2007;56(2):555–567.
  15. Hochberg MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommen1. Glucosamine and chondroitin for osteoarthritis pain. Arthritis Foundation. https://www.arthritis.org/health-wellness/treatment/complementary-therapies/supplements-and-vitamins/glucosamine-chondroitin-osteoarthritis-pain. Accessed Oct. 24, 2020.
    2. N-acetyl glucosamine (NAG). Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
    3. Osteoarthritis. National Institute of Arthritis and Musculoskeletal and Skin Diseases. https://www.niams.nih.gov/health-topics/osteoarthritis. Accessed Oct. 24, 2020.
    4. Glucosamine sulfate. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
    5. Pizzorono JE, et al., eds. Glucosamine. In: Textbook of Natural Medicine. 5th ed. Elsevier, 2021. https://www.clinicalkey.com. Accessed Oct. 24, 2020.
    6. Vasiliadis HS, et al. Glucosamine and chondroitin for the treatment of osteoarthritis. World Journal of Orthopedics. 2017; doi:10.5312/wjo.v8.i1.1.
    7. Glucosamine hydrochloride. Natural Medicines. https://naturalmedicines.therapeuticresearch.com. Accessed Oct. 24, 2020.
    8. Rubin BR, et al. Oral polymeric N-acetyl-D-glucosamine and osteoarthritis. Journal of the American Osteopathic Association. 2001; https://jaoa.org/article.aspx?articleid=2092565. Accessed Oct. 28, 2020.
    9. Ali AA, Lewis SM, Badgley HL, et al. Oral glucosamine increases expression of transforming growth factor β1 (TGFβ1) and connective tissue growth factor (CTGF) mRNA in rat cartilage and kidney: implications for human efficacy and toxicity. Archives of Biochemistry and Biophysics. 2011;510(1):11–18.
    10. Cahlin BJ, Dahlström L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics. 2011;112(6):760–766.
    11. Clegg DO, Reda DJ, Harris CL, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. New England Journal of Medicine. 2006;354(8):795–808.
    12. Dostrovsky NR, Towheed TE, Hudson RW, et al. The effect of glucosamine on glucose metabolism in humans: a systematic review of the literature. Osteoarthritis and Cartilage. 2011;19(4):375–380.
    13. Gabay C, Medinger-Sadowski C, Gascon D, et al. Symptomatic effects of chondroitin 4 and chondroitin 6 sulfate on hand osteoarthritis: a randomized, double-blind, placebo-controlled clinical trial at a single center. Arthritis & Rheumatism. 2011;63(11):3383–3391.
    14. Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis & Rheumatism. 2007;56(2):555–567.
    15. Hochberg MC, Altman RD, April KT, et al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care & Research. 2012;64(4):465–474.
    16. Knudsen JF, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. Pharmacotherapy. 2008;28(4):540–548.
    17. Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine. 2002;162(18):2113–2123.
    18. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251–256.
    dations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care & Research. 2012;64(4):465–474.
  16. Knudsen JF, Sokol GH. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. Pharmacotherapy. 2008;28(4):540–548.
  17. Pavelká K, Gatterová J, Olejarová M, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Archives of Internal Medicine. 2002;162(18):2113–2123.
  18. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. 2001;357(9252):251–256.
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